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Other ointments

Outwardly, it is recommended to treat ulcers with Acemine ointment, Furacilin, Gramicidin paste.

With long-standing forms of syphilis, in addition to antibiotics, a course of vitamins is mandatory - an oily solution of vitamin A, vitamins B6, B12 in the form of injections, nicotinic and ascorbic acid to relieve inflammatory processes. Such measures are relevant for damage to the nervous system, parts of the brain.

Syphilis therapy is not an easy and long task, and the success of treatment depends on an individual approach and a combination of different types of drugs and techniques. Self-administration of drugs is unacceptable, as it can result in death. It is easier to cure a dangerous disease in the early stages, so you can’t hesitate - if you find the first signs, you should immediately seek medical help.

Prostatitis is an exclusively male disease and develops when various pathogenic microorganisms enter the prostate gland, which lead to the development of the inflammatory process in the prostate. That is why most specialists prescribe Amoxiclav for prostatitis, as it will help to cope with pathogens..

Amoxiclav (also amoxicillin clavulanate online) belongs to the category of antibacterial agents, therefore it can not be used on its own, it is mandatory to consult a doctor. The drug can be used in situations where the patient does not have the opportunity to quickly pass tests, but treatment must be started now, despite the fact that the pathogen has not yet been determined. The medicine can be used in the treatment regimen of almost all forms of bacterial prostatitis, since it has a negative effect on most bacterial pathogens.

Indications for use

Augmentin is indicated for the treatment of the following infections in adults and children:

Acute bacterial sinusitis

Acute otitis media

Exacerbations of chronic bronchitis

Infections of the skin and soft tissues, in particular phlegmon, animal bites, severe dental abscess with spreading phlegmon.

Infections of bones and joints, in particular osteomyelitis

Formal guidelines for the rational use of antibacterial agents should be taken into account..

Amoxiclav contraindications

 

• hypersensitivity to any of the components of the drug;
• hypersensitivity in history to penicillins, cephalosporins and other beta-lactam antibiotics;
• history of evidence of cholestatic jaundice and / or impaired liver function caused by taking amoxicillin / clavulanic acid;
• Infectious mononucleosis;
• pimpholeukemia.

 

Carefully

With a history of pseudomembranous colitis, diseases of the gastrointestinal tract, liver failure, severe impaired renal function, pregnancy, lactation, with simultaneous use with anticoagulants.

Use during pregnancy and during breastfeeding

Animal studies have not revealed data on the dangers of taking the drug during pregnancy and its effect on fetal development.

In one study in women with premature rupture of the amniotic membranes, it was found that prophylactic therapy with amoxicilpin / clavulanic acid may be associated with an increased risk of necrotizing enterocolitis in newborns. During pregnancy and lactation, the drug is used only if the intended benefit to the mother outweighs the potential risk to the fetus and child. Amoxicillin and clavulanic acid in small quantities pass into breast milk, if there are clear indications, the period of breastfeeding should be continued only if there are clear indications.

In infants receiving breastfeeding, sensitization, diarrhea, and candidiasis of the mucous membranes of the mouth are possible. In such cases, breastfeeding should be discontinued..

Pharmacokinetics

After intravenous administration of the drug in doses of 1.2 and 0.6 g, the average values ​​of the maximum concentration in blood plasma (C _max ) amoxicillin is 105.4 and 32.2 μg / ml, clavulanic acid is 28.5 and 10.5 μg / ml, respectively. Both components are characterized by a good volume of distribution in body fluids and tissues (lungs, middle ear, pleural and peritoneal fluids, uterus, ovaries). Amoxicillin also penetrates the synovial fluid, liver, prostate gland, palatine tonsils, muscle tissue, gall bladder, secretion of the sinuses, bronchial secretion. Amoxicillin and clavulanic acid do not cross the blood-brain barrier in uninflamed meninges.

Active substances cross the placental barrier and, in trace concentrations, are excreted in breast milk..

Binding to plasma proteins for amoxicillin is 17-20%, for clavulanic acid - 22-30%.

Both components in the liver are metabolized. Amoxicillin is partially metabolized - 10% of the administered dose, clavulanic acid undergoes intensive metabolism - 50% of the administered dose.

After intravenous administration of amoxicillin + clavulanic acid in doses of 1.2 and 0.6 g, the half-life (T1 / 2) for amoxicillin is 0.9 and 1.07 h, for clavulanic acid 0.9 and 1.12 h.

Amoxicillin is excreted by the kidneys (50-78% of the administered dose) almost unchanged by tubular secretion and glomerular filtration. Clavulanic acid is excreted by the kidneys by glomerular filtration unchanged, partially in the form of metabolites (25-40% of the administered dose) within 6 hours after taking the drug. Small amounts can be excreted through the intestines and lungs..

In patients with severe renal failure, the elimination half-life increases to 7.5 hours for amoxicillin and up to 4.5 hours for clavulanic acid.

Both components are removed by hemodialysis and minor amounts by peritoneal dialysis..

Pregnancy and lactation

In studies of reproductive function in animals, oral and parenteral administration of Augmentin ® did not cause teratogenic effects..

In a single study in women with premature rupture of the membranes, it was found that prophylactic drug therapy may be associated with an increased risk of necrotizing enterocolitis in newborns. http://www.mdpi.com/journal/antibiotics Like all medicines, Augmentin ® is not recommended for use during pregnancy, unless the expected benefit to the mother outweighs the potential risk to the fetus..

The drug Augmentin ® can be used during breastfeeding. With the exception of the possibility of developing diarrhea or candidiasis of the mucous membranes of the oral cavity associated with the penetration into the breast milk of trace amounts of the active ingredients of the drug, no other adverse effects were observed in breast-fed infants. In the event of adverse effects in breast-fed infants, breast-feeding should be discontinued..

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